伟德国际(bevictor)官方网站-源自英国始于1946

方春副教授

所在系所: 动物医学

办公电话: 18771929732

通讯地址: 荆秘路88号伟德bevlctor1946源于英西校区5-904

电子邮件: fangchun@zju.edu.cn

个人主页:fangchun@yangtzeu.edu.cn

教育背景

2010/09-2015/06，浙江大学，动物科学公司，博士 2006/09-2010/06，江西农业大学，伟德bevlctor1946源于英，学士
工作经历

2017/08至今，伟德bevlctor1946源于英，动物科学公司 2015/07-2017/07，武汉大学，实验动物中心
出访及挂职经历
研究方向

食源性病原微生物感染与致病机理
科研项目

1.国家自然科学基金青年基金，31802208，分子伴侣PrsA2介导单增李斯特菌内化素B锚定与感染的机制，主持； 2.湖北省教育厅青年人才项目，Q20221302, 单增李斯特菌GAD系统抗酸应激的调控机制研究，主持 3.农业部畜禽细菌病防治制剂创制重点实验室开放课题，KLPCAAB-2018-05，单增李斯特菌GadR4在谷氨酸脱羧酶抗酸应激中的调控作用及其机制，主持； 4.浙江省动物预防医学重点实验室开放课题，ZPKLPVM2017KFKT003，单增李斯特菌GadT2/D2的抗酸应激作用及其调控机制，主持
代表性论文专著

1.Yang, Yuting#; Qin, Yi#; Tian, Lanxin; Zheng, Minghao; Xiao, Jinhua; Han, Xu; Fang, Xiaowei; Fang, Chun*. The transcriptional factor MntR mediates hyperosmotic stress resistance by positively regulating the glycine betaine uptake system Gbu in Listeria monocytogenes. Food Bioscience, 2025, 68:106694. 2.Fang, Xiaowei#; Yuan, Mei#; Zheng, Minghao; Guo, Qian; Yang, Yuting; Yang, Yuying; Liang, Xiongyan; Liu, Jing *; Fang, Chun*. Deletion of glycosyltransferase galE impairs the InlB anchoring and pathogenicity of Listeria monocytogenes. Virulence, 2024, 15(1): 2422539. 3.Fang, Xiaowei#; Yang, Yuying#; Guo, Qian; Zhang, Yu; Yuan, Mei; Liang, Xiongyan; Liu, Jing; Fang, Shouguo*; Fang, Chun*. Two-component system LiaSR negatively regulated the acid resistance and pathogenicity of Listeria monocytogenes 10403S. Food Microbiology, 2024, 119:104428. 4.Yang, Yuting; Hong, Jiajun; Zhang, Zheng; Zheng, Minghao; Zhao, Jingang; Fang, Xiaowei; Liang, Xiongyan; Liu, Jing*; Yang, Yuying; Tian, Guangming; Fang, Chun*. Oral supplementation with lactic acid bacteria improve the intestinal epithelial barrier and gut microbiota of broiler chicks to alleviate Salmonella Enteritidis infection. Poultry Science, 2024, 103:104385. 5.Zhang, Yu#; Guo, Qian#; Fang, Xiaowei; Yuan, Mei; Liang, Xiongyan; Liu, Jing; Yang, Yuying; Fang, Chun*. Destroying glutathione peroxidase improves the oxidative stress resistance and pathogenicity of Listeria monocytogenes. Frontiers in Microbiology, 2023,14:1122623. 6.Fang, Xiaowei; Zhang, Yu; Guo, Qian; Yuan, Mei; Liang, Xiongyan; Liu, Jing; Fang, Shouguo; Yang, Yuying; Fang, Chun*. GadR4 mediates the acid resistance and pathogenicity of Listeria monocytogenes 10403S by negatively regulating the gadT2/gadD2 cluster. Food Microbiology, 2023, 112:104248. 7.Guo, Qian; Zhang, Yu; Fang, Xiaowei; Yang, Yuting; Liang, Xiongyan; Liu, Jing; Fang, Chun*. Two-component system virS/virR regulated biofilm formation of Listeria monocytogenes 10403S. Food Bioscience, 2023, 55:102973. 8.Zhang, Yu#; Fang, Xiaowei#; Chen, Xueyang; Wang, Houkun; Liu, Jing; Liang, Xiongyan; Gu, Yufang; Fang, Chun*; Yang, Yuying*. Bacillus cereus causes fatal disease in soft-shelled turtle (Trionyx sinensis). Aquaculture, 2022, 547 (737473): 1-8. 9.Fang, Xiaowei#; Hu, Wei#; Zhang, Yu; Wang, Chen; Luo, Qingping; Wu, Hui; Liang, Xiongyan; Gu, Yufang; Fang, Chun*; Yang, Yuying*. Roles of Histidine Kinase Gene yycG in the Pathogenicity of Listeria monocytogenes. Kafkas Universitesi Veteriner Fakultesi Dergisi, 2020, 26 (5): 679-686. 10.Fang, Chun#; Fang, Xiaowei#; Chen, Xueyang; Wang, Chen; Liang, Xiongyan; Gu, Yufang; Fang, Weihuan; Yang, Yuying. Evaluating the Contribution of Acid Resistance Systems and Probing the Different Roles of the Glutamate Decarboxylases of Listeria monocytogenes Under Acidic Conditions. Kafkas Universitesi Veteriner Fakultesi Dergisi, 2020, 26 (2): 231-238. 11.Gong, Jun#; Fang, Chun#; Zhang, Peng#; Wang, Pi-Xiao; Qiu, Yixing; Shen, Li-Jun; Zhang, Li; Zhu, Xue-Yong; Tian, Song; Li, Feng; Wang, Zhihua; Huang, Zan; Wang, Aibing; Zhang*, Xiao-Dong*; She, Zhi-Gang*. Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice. Hepatology 2019, 69 (2), 524-544. 12.Fang, Chun#; Chen, Xueyang; Liang, Xiongyan; Fang, Xiaowei; Gao, Keli; Chen, Jing; Gu, Yufang; Yang, Yuying*. The Effect of Single Amino Acid Substitution in SecA2 on Protein Translocation and Pathogenicity of Listeria monocytogenes. Kafkas Universitesi Veteriner Fakultesi Dergisi 2019, 25 (5), 665-672. 13.Wang, Xiaozhan#; Mao, Wenzhe#; Fang, Chun#; Tian, Song; Zhu, Xueyong; Yang, Ling; Huang, Zan*; Li, Hongliang*. Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression. Journal of Hepatology 2018, 68 (1), 118-129. 14.Fang, Chun; Shan, Ying; Cao, Tong; Xia, Ye; Xin, Yongping; Cheng, Changyong; Song, Houhui; Li, Xiaoliang; Fang, Weihuan*. Prevalence and Virulence Characterization of Listeria monocytogenes in Chilled Pork in Zhejiang Province, China. Foodborne Pathogens and Disease 2016, 13 (1), 8-12. 15.Fang, Chun; Cao, Tong; Shan, Ying; Xia, Ye; Xin, Yongping; Cheng, Changyong; Song, Houhui; Bowman, John; Li, Xiaoliang; Zhou, Xiangyang; Fang, Weihuan*. Comparative Genomic Analysis Reveals That the 20K and 38K Prophages in Listeria monocytogenes Serovar 4a Strains Lm850658 and M7 Contribute to Genetic Diversity but Not to Virulence. Journal of Microbiology and Biotechnology 2016, 26 (1), 197-206. 16.Fang, Chun; Cao, Tong; Cheng, Changyong; Xia, Ye; Shan, Ying; Xin, Yongping; Guo, Ningning; Li, Xiaoliang; Song, Houhui; Fang, Weihuan*. Activation of PrfA results in overexpression of virulence factors but does not rescue the pathogenicity of Listeria monocytogenes M7. Journal of Medical Microbiology 2015, 64, 818-827. 17.洪嘉俊, 肖金华, 张政, 杨雨婷, 方春*, 韩旭*. sod基因缺失对单增李斯特菌10403S抗氧化应激作用的影响. 中国畜牧兽医, 2025, 52(4): 1776-1783. 18.张政, 肖金华, 张钰, 杨雨婷, 洪嘉俊, 方春*, 韩旭*. 单增李斯特菌谷胱甘肽过氧化物酶报告系统的构建及其调控因子筛选. 畜牧与兽医, 2025, 57(8): 61-68. 19.郑明浩, 郭骞, 刘芳, 梁雄燕, 刘晶, 杨玉莹, 田光明*, 方春*. 半乳糖基转移酶gttA基因缺失对4b型单增李斯特菌致病性的影响. 中国畜牧兽医, 2024, 51 (3): 1214-1222. 20.秦祎, 胡文洁, 方小伟, 郭骞, 田篮鑫, 刘芳*, 方春*. 脂磷壁酸合成酶ltaS基因缺失对产单核细胞李氏杆菌致病性的影响. 畜牧兽医学报, 2024, 55 (2): 670-679. 21.胡文洁, 方小伟, 郭骞, 杨雨婷, 刘晶, 梁雄燕, 杨玉莹, 方春*. 分子伴侣prsA2基因缺失对单增李斯特菌致病性的影响. 中国畜牧兽医, 2024, 51 (1): 338-346. 22.田篮鑫, 杨雨婷, 秦祎, 张政, 田光明*, 方春*. 谷氨酸脱氢酶gdhA基因缺失对单增李斯特菌抗氧化应激的影响. 中国畜牧兽医, 2024, 51(9): 3771-3779. 23.杨雨婷, 韩旭, 肖金华, 方小伟, 梁雄燕, 刘晶*, 方春*. gltC基因缺失对单增李斯特菌10403S抗酸应激能力的影响. 中国畜牧兽医, 2024, 51(7): 3077-3085. 24.郭骞, 张钰, 方小伟, 袁梅, 郑明浩, 刘芳, 方春*. 双组份系统resE/resD基因缺失对单增李斯特菌抗渗透压应激能力及致病性的影响. 中国畜牧兽医, 2023, 50 (9): 3853-3860. 25.张钰, 方小伟, 袁梅, 郭骞, 梁雄燕, 刘晶, 杨玉莹, 方春*. 单增李斯特菌双元调控系统lmo1060/lmo1061缺失株的构建及其抗酸应激能力. 畜牧与兽医, 2022, 54 (1): 77－83. 26.陈凌波, 张钰, 方小伟, 吉俊芝, 方春*, 杨玉莹*. 双元调控系统LisRK对单增李斯特菌抗酸应激与侵袭力作用的研究. 中国畜牧兽医, 2022, 49 (2): 416-423. 27.安妮, 张钰, 方小伟, 梁雄燕, 刘晶, 杨玉莹, 方春*. 单增李斯特菌双元调控系统hssS/hssR缺失株的构建及其生物学特性. 畜牧兽医学报, 2022, 53 (3): 867-874. 28.郭骞, 张钰, 方小伟, 安妮, 袁梅, 方春*. 糖基翻转酶gtcA基因缺失降低单增李斯特菌1/2a血清型菌株致病性的研究. 中国畜牧兽医, 2022, 49 (6): 2298-2306. 29.袁梅#, 吉俊芝#, 张钰, 何琴, 吴敏, 沈爽, 腾琳, 方春*. 糖基转移酶GalU对单增李斯特菌致病性的影响. 畜牧与兽医. 2022, 54 (7):65-70. 30.林垲, 雷婷, 吉俊芝, 胡雪然, 熊艳玲, 毛凯佑, 双乐乐, 刘文静, 方春*. 蜡样芽孢杆菌溶血素BL的表达及多克隆抗体的制备. 黑龙江畜牧兽医. 2021, (7): 81-85. 31.方小伟, 施鹏, 彭鼎, 杨玉莹, 方春*. 单增李斯特菌InlB的原核表达与多克隆抗体制备. 黑龙江畜牧兽医. 2020, (10): 51-54. 32.王宜, 方小伟, 刘慧娟, 万娇红, 郭骞, 张钰, 田棋, 方春*. 单核细胞增生李斯特菌SigB调控GadD3的抗酸应激作用. 动物医学进展. 2020, 41 (1): 45-49.
教学工作

主讲本科生《兽医微生物学》、《药物分析》和研究生《细胞培养实验技术》等课程。
软件版权登记及专利
学术兼职
荣誉奖励

教育背景

工作经历

出访及挂职经历

研究方向

科研项目

代表性论文专著

教学工作

软件版权登记及专利

学术兼职

荣誉奖励